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Engineering of Advanced Materials

Friedrich-Alexander-Universität Erlangen-Nürnberg

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Cluster of Excellence
Engineering of
Advanced Materials (EAM)

Nägelsbachstrasse 49b
91052 Erlangen, Germany
eam-administration@fau.de
01. December 2017

Picture of the month: Nanodiamonds entrapped by neutrophil extracellular traps (NETs)

Due to the increasing use of nanotechnology, humans are daily exposed to nanoparticles which may trespass the body’s barriers. Within the EAM project Nanosafety, we showed that small (10 – 40 nm) hydrophobic nanoparticles lead to the fast damage of plasma membranes and instability of the lysosomal compartment of cells promoting the release of neutrophil extracellular traps (NETs). In contrast, larger particles (100 – 1000 nm) behaved rather inertly. NETs effectively immobilized and entrapped nanoparticles and limited initial inflammatory responses, thereby preventing tissue damage. Thus, NETosis represents a defense mechanism of the immune system to cope with nanoparticles.

Reference
Muñoz, L. E.; Bilyy, R.; Biermann, M. H. C.; Kienhöfer, D.; Maueröder, C.; Hahn, J.; Brauner, J. M.; Weidner, D.; Chen, J.; Scharin-Mehlmann, M.; Janko, C.; Friedrich, R. P.; Mielenz, D.; Dumych, T.; Lootsik, M. D.; Schauer, C.; Schett, G.; Hoffmann, M.; Zhao, Y.; Herrmann, M.
Nanoparticles size-dependently initiate self-limitating NETosis-driven inflammation.
PNAS 2016, 113, E5856 – E5865.
Copyright 2016 National Academy of Sciences.

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